The Engineered T-Cell Receptor in
Fusion Proteins, Antibodies & Cells: Emerging Opportunities for the
Biopharmaceutical Industry
A
comparative analysis and assessment of TCR technologies, pipelines and
companies from an industry perspective
Therapeutic
monoclonal antibodies have become an increasingly successful treatment
modality with sales of US$ 65 bln in the year 2012 and with an average
(continuous) annual growth rate from 2006 to 2012 of 18.9%. While
antibody technologies are steadily evolving, the spectrum of druggable
targets for monoclonal antibodies has remained limited to extracellular
antigens, albeit including proteins, carbohydrates and glycolipids.
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Access
to druggable, IP-protected and validated new targets is a major
bottleneck in the biopharmaceutical industry. Technologies which can
deliver both new targets and the corresponding treatment modality, can
expect significant financial acknowledgement.
The
T-cell receptor (TCR) has recently emerged as a means to target peptide
antigens derived from intracellular proteins, however, in a major
histocompatibility complex (MHC)-restricted manner. The first companies
have overcome significant technical hurdles in putting together a library
of viable new TCR-targeted antigens and establish the corresponding
standardized protein- and cell-based therapeutic frameworks.
This
report entitled „The Engineered T-Cell Receptor in Fusion Proteins, Antibodies
& Cells: Emerging Opportunities for the Biopharmaceutical Industry “
published in Ocotber 2013 describes chances and pitfals in exploiting the
opportunities which offers the engineered T-cell receptor as integral
part of fusion proteins, antibodies and cellular products. The key
success factors are highlighted, the technical challenges described and
solutions presented.
Benefits
from the report:
- Identify players in the field, from industry and academia;
- Find out which TCR technologies are valued by Big Pharma and Biotech;
- Understand the value of intracellular antigens targeted by the TCR;
- Recognize the challenges of TCR-based therapeutics and their solutions;
- Learn which TCR-based therapeutics are attractive for partnering;
- Find out which TCR therapeutic approaches are not yet tapped.
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